possible cure

Experimental MS Vaccine Proves Safe in Early Test
It could lead to individualized treatments for other autoimmune diseases, researchers say
By Steven Reinberg
Posted 8/13/07
MONDAY, Aug. 13 (HealthDay News) -- An experimental DNA vaccine to fight multiple sclerosis is safe and may also be effective, results of a small Canadian trial suggest.

The vaccine, called BHT-3009, works by preventing the immune system from attacking the myelin sheaths that protect nerve cells in the brain and spinal cord. The destruction of myelin eventually destroys a nerve cell's axon, which prevents cells from transmitting messages and is one of the hallmarks of MS.

"This was an early trial of a new class of drugs for autoimmune disease in general and for MS in particular," said lead researcher Dr. Amit Bar-Or, of McGill University's Montreal Neurological Institute.

The idea of the vaccine is to change the immune cells that target the nervous system, Bar-Or said. "What we want to do is focus on just those cells that are involved in the disease process," he said. "So antigen-specific therapies are designed to try to modify or eliminate only those bad-guy cells that are involved in the disease process."

The vaccine makes use of a backbone of DNA onto which is attached myelin basic protein, which is a component of myelin. When you inject it, the vaccine reduces the body's ability to attack myelin, Bar-Or explained.

The findings were published online Monday in Archives of Neurology and were expected to be published in the October print issue of the journal.

According to the National Multiple Sclerosis Society, the disease's symptoms are unpredictable and vary from person to person, and even from time to time in the same person. One person may experience abnormal fatigue, while another might have severe vision problems. A person with MS could have loss of balance and muscle coordination, making walking difficult. Another person could have slurred speech, tremors, stiffness and bladder problems.

In the new study, Bar-Or and his colleagues gave the vaccine to 30 patients with relapsing-remitting MS, which is characterized by alternating periods of symptoms and then relief from those symptoms. At one, three, five and nine weeks, the study participants received injections of BHT-3009 or a placebo. After 13 weeks, those who had been given a placebo were given four injections of BHT-3009.

The researchers evaluated the patients using MRI scanning. They found that the vaccine was well tolerated and also appeared to produce antigen-specific immune changes that stopped the destruction of myelin. These changes were seen in the reduction in the number of CD4+ T-cells -- white blood cells that target myelin.

Bar-Or cautions that much more work remains to be done to see if the vaccine is effective. Whether it represents a possible cure is unknown; all that is known right now is that it's safe. "The trial did provide a biological proof of concept, he said. "In addition, there are other targets in the brain that are involved in MS.

"Now that this biological principle appears to be sound, one could develop DNA vaccines to different targets," he said. "Ideally one could develop a cocktail that deals specifically with an individual's MS."

Based on theses findings, the Montreal researchers have started a phase 2 trial testing BHT-3009 on 290 patients with MS.

The same approach could also be used to treat other autoimmune diseases, such as type 1 diabetes, lupus, myasthenia gravis and rheumatoid arthritis, the researchers said.

Patricia O'Looney, vice president of biomedical research programs at the National Multiple Sclerosis Society, thinks this new approach is promising, but the concept still needs to be proven in larger trials.

"This is like science fiction. It's something that wouldn't have even been thought about 10 years ago," O'Looney said.

Still, the results offer hope, she said.

"This is a fascinating approach to try to control the immune activity with folks with MS," she said. "We are always looking for new ways to help people with MS. It is important that this is a novel idea, and we will just have to watch and see if it goes forward."

For more on multiple sclerosis, visit the National Multiple Sclerosis Society.

Spray Away MS!!!

Posted: 04 Mar 2007, 17:29
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I can only say that I'm at a loss for words!

here's the email our Friends received

:-)
stan

**********************THE EMAIL IS BELOW************************************



----------------------I Am Beating MS With The XXX Spray----------------------------

I have had MS since 1994. In 2002 my health really began to decline. I had to use a walker or wheelchair to get where I wanted to go. I decided to look for Alternative Medicine for help. I had received an e-mail from xxxxxxxxxx about a xxxxxx spray and treatment for MS being offered in the Bahamas .

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He sat me down and gave me 3 sprays under my tongue, waited 5 minutes and administered another 3 sprays.

After 5 minutes again he asked me to stand and hold my balance.

I held my balance for 2 1/2minutes 30 seconds with my eyes closed. Amazing. XXXXX XXXXX, a Bio Medical Engineer is one of my best friend's who helped me get to the Bahamas claimed that if she had not seen the results with her own eyes she never would have believed how quickly my balance had improved. XXXXX taught me exercises to do in the swimming pool to get my right leg working again and stronger. After 2 days of working out in the gym and the swimming pool, 2 hours every day. I felt confident enough to go Parasailing. I needed help walking through the sand and was caught on the landing in the boat. Bahamas was absolutely beautiful when you are up in the air being pulled by a boat ... and getting your life back with the XXXXX XXXXXX spray. I am doing Physical Therapy 2 days a week and will start using the Power Plate. I believe with peptide spray and hard work we can improve our lives.

I am beating MS and a bad Spine Injury; it just takes hard work, determination and faith. MS brings us all down even if you were superman it will.

The XXXXX XXXXXXX spray helps our brain command our nerves to walk or move our arms etc.

The opportunity is there, P. T. and the XXXXXX spray open the door for you to have a manageable life again. If you work hard you can improve your life. I am only 44 and was refusing to get worse. I thank God and all the people at XXXXXXXXX XXXXXX Foundation for giving me the opportunity to get stronger and regain my self confidence plus making my life more manageable.

XXXXXX XXXXXX


*****************************END OF EMAIL*************************************

THIS SPRAY IS NOT A JOKE! IT IS BEING SOLD TO OUR FRIENDS NOW!

It is important that you tell our Friends how you feel about this! Many Friends have written me thinking that this spray is a new miracle Cure for MS!!

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- stan